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Newt Scamander was officially expelled from Hogwarts for endangering human life with a beast. However, the truth of the incident is that he took the blame for an experiment gone wrong conducted by his close friend, Leta Lestrange, involving a Jarvey. Although he was expelled, Albus Dumbledore argued strongly in his defense. Newt was allowed to keep his wand (unlike Hagrid), possibly due to Dumbledore's intervention or the expulsion not being fully enforced.
Newt Scamander was expelled from Hogwarts School of Witchcraft and Wizardry for endangering human life with a magical creature.
The specific details are as follows:
The summary omits the crucial fact that Newt took the blame for Leta Lestrange. This is the true reason for the expulsion and explains his character's self-sacrificing nature.
The beast was a Jarvey (a magical ferret-like creature), a detail found in production notes and the sequel, though not named in the 2016 film dialogue.