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In the film Twelve Monkeys (1995), the most crucial action made by the lead character, James Cole (played by Bruce Willis), is his attempt to stop Dr. Peters from boarding a plane at the Philadelphia International Airport to spread the virus.
This action is the narrative's "causal loop" anchor. It is crucial because it represents the moment Cole identifies the true source of the plague (correcting the scientists' false lead on the Army of the Twelve Monkeys) and attempts to intervene, an act that results in his death and fulfills the traumatic memory/vision he had as a child.
Two primary characters help Cole perform this final, crucial action:
While the scientists from 2035 (specifically Dr. Jones, who is seen on the plane at the very end) are ultimately the ones who benefit from Cole's intelligence-gathering, it is the combination of Railly’s eyes and José’s weapon that enables Cole’s final, pivotal act.
The summary correctly states the scientists benefit, but omits the specific implication of Dr. Jones' presence: she is likely there to obtain a sample of the pure virus to create a cure in the future, rather than to prevent the outbreak (which has already happened in her timeline).
In Twelve Monkeys (1995), the most crucial action by James Cole is his attempt to assassinate Dr. Peters at the Philadelphia airport to prevent the release of the virus. He is helped by Dr. Kathryn Railly, who identifies Peters from a newspaper photograph, and José, a fellow time-traveler who gives him a handgun and instructs him to follow orders. Cole's action results in his death (witnessed by his younger self, completing the loop), but his identification of Peters allows the future scientist Dr. Jones to locate the virus sample on the plane.