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Yes, the majority of the indigenous extras and the lead actor Nilbio Torres (Young Karamakate) had no prior acting experience. Torres was a farmer and rubber tapper from the Cubeo community. The other lead, Antonio Bolívar Salvador (Old Karamakate), had very limited experience, having appeared in a short film roughly 20-25 years prior. However, he had a negative experience on that project, feeling it was disrespectful to his culture, and had vowed not to act again until persuaded by director Ciro Guerra. Guerra described the cast as being "plucked from nearby farms and river tribes."
The majority of the indigenous people cast in Embrace of the Serpent, including the extras and many of the main actors, had no prior professional acting experience before the film.
The director, Ciro Guerra, deliberately sought to populate the cast with individuals "plucked from nearby farms and river tribes," noting that "many of whom had never before encountered a camera." Approximately 60 people from indigenous communities within the Amazon worked with the production.
Specific details regarding the film's main indigenous actors, who came from this non-professional background, include:
Some sources indicate Torres initially sought work as a production assistant or refused to be an extra, demanding a lead role, which adds agency to his casting story.
The gap was closer to 20-25 years, rather than just 'over 10'.