This is an experiment in AI-driven contextualization. The material below was produced using SIFT Toolbox, a human-in-the-loop LLM-based contextualization toolbox designed to accelerate fact-checking and sensemaking. Findings should be considered draft findings, lightly checked at best. This check of the report was done as a test to check the robustness and usefulness of the Toolbox.

Context Report: Psychotherapy vs Antidepressants Citation Analysis

Antidepressant prescription rates in teens increased by 14-fold between 1987 and 2014, even though a systematic overview shows that psychotherapy is just as effective as drugs in the short term, and potentially more effective in the long term.

Cited Reference: Cuijpers, P., Miguel, C., Harrer, M., Plessen, C. Y., Ciharova, M., Papola, D., Ebert, D., & Karyotaki, E. (2023). Psychological treatment of depression: A systematic overview of a 'Meta-Analytic Research Domain'. Journal of affective disorders, 335, 141–151.

Summary: The cited study does support that psychotherapy has comparable short-term effectiveness to antidepressants and suggests possible long-term advantages. Critically, the study focuses on adult populations and explicitly states that treatment effects "are significantly smaller in children and adolescents," making direct application to teenage antidepressant prescribing problematic. The citation also omits the study's key finding that combined psychotherapy and pharmacotherapy is more effective than either treatment alone, both short-term and long-term.

Core Context

Sources Table

Source Description of Position on Issue Link
Cuijpers et al. (2023) - Primary Citation Psychotherapy has comparable short-term effects to pharmacotherapy and is "probably more effective at the longer term." Combined treatment superior to either alone. Effects smaller in children/adolescents. ScienceDirect
PubMed Abstract - Same Study Confirms study focuses on adult populations with qualified language about long-term effects. Notes significantly smaller effects in youth. PubMed
Cuijpers et al. (2020) Network Meta-Analysis Combined treatment more effective than psychotherapy or pharmacotherapy alone in short-term treatment of moderate depression. No significant differences between psychotherapy and pharmacotherapy alone. World Psychiatry
Karyotaki et al. (2016) Long-term Effects Combined therapy shows superior enduring effects compared to antidepressants alone. Psychotherapy adequate alternative to combined treatment in acute phase. PubMed
Frontiers in Psychiatry (2024) Enduring Effects Meta-analysis showing psychotherapy superior to pharmacotherapy for long-term outcomes, but combined treatment best overall for preventing relapse/recurrence. Frontiers
Cuijpers et al. (2013) Direct Comparisons No statistically significant difference between psychotherapy and pharmacotherapy overall (g=0.02, 95% CI: −0.07 to 0.10). World Psychiatry